ORIGINALLY: you needed a SRLE setup and this pack was designed as an add-on. Hence why the integration guide's still around, as a bit of a legacy service to anyone who's coming at it from that angle.
We then decided it was easier if the whole guide was standalone, so you didn't need worry about Neovalen's guide, thus saving having to have many tabs open etc. So if you use the first link in the OP, you should be fine to go from dead vanilla to fully modded with at most maybe 2 tabs open at once.
IF and WHEN SKSE arrives for SSE, we'll port this guide over for it too. Though this Classic version will also remain for those who don't want to go to SSE.
I've not heard of anyone having any huge issues with Windows 10. I don't use it and won't use it, so Maybe take my words on that with a grain of salt. The memory issue will likely mean the occasional crash, I'd imagine. If you stay with 2k's 99% of the time, maybe 4K if you want to risk it for textures for your char and NPC's you will hopefully limit that even too.
Edited by Nozzer66, 20 March 2017 - 11:02 PM.