I can't test it at the moment, I'm still version 1607 of Win 10 and the so-called 'Creator' update is 1703. However from the few reports I've gotten so far I think it may be a setting that can be turned off. Failing that I hae reached out to a few coders that may be able step in and do "fix" if necessary, still in the discussion phase at the moment.
The big difference with MO and any other manager is the hooking process that @Tannin developed, he expanded on his thesis project about malware and hence the underlying code looks to Windows as malicious and may be turned off somehow. Having the ability to keep a clean 'Data' folder, and the use of multiple profiles is a good selling point of MO/MO2 but if that fails it may be time to call it a day and look elsewhere.
As for Windows 7, I doubt there are any concerns with it. Microsoft has just as much wiped their hands of it and have stated they will no longer support it in newer CPUs so I can't see any fancy patches or updates coming along that render MO broken on that platform.