OK, I decided yesterday to start a new play through of New Vegas so I started out with a clean install. Which for me means that the dlc's are cleaned and I have only NVSE and Wrye Flash in the main Steam Directory along with NVEC. Currently, when I attempt to start the game up using 4GBNV, the one reccomended in the guide, I have an instant CTD. This is strange as I have had the program working before with no problems at all. In fact, the only differences are updated mod files that I downloaded and that is all.
The only .ini tweaks I have done are the ones posted in the guide as well as using Bethini with a high setting along with "reccommended .ini tweaks" ticked.