I'm having a very similar issue as a previous poster, with the area by the Red Rocket Station next to Megaton. The Station itself was visible at a distance, but as I approached, lots of Red-Exclamation-Points popped up, and the whole station went black. Oh, and the Nuka Cola machine is mistextured, and twisting like a Lovecraftian wall decoration. When this happens, I can no longer access the system menu (hitting ESC does nothing), and if I open my Pip-Boy, I have the same blue icons the OP mentioned. I can only exit by hitting Alt+F4.
Deactivating the NMC texture pack seems to have fix the "station turns black" problem, but that's the only progress deactivating texture packs one at a time has helped.
I should note that I got through the entirety of Vault 101 without a single visual hiccup.
Edited by Barachiel, 10 October 2017 - 09:05 PM.