I just went back to Skyrim and the Creation Kit after several months of not playing, and I'm encountering some major problems. Primarily, it's that even with the default MO profile, launching Skyrim + SKSE via MO, new game sits on the title screen infinitely, and continue gives me the warning about missing content (even with no mods active, on a vanilla save) and then does an immediate CTD when I clear the message. If I use the vanilla launcher, the game runs fine, both new games and continuing save files. I've validated files with Steam. I found this problem because I was trying to test out a build and the COC command wasn't working.
So I guess my question is should I uninstall/reinstall MO? SKSE is the same version it was when I last played, and to my knowledge absolutely nothing has changed about any part of my configuration. I'm just assuming the problem is with MO, but I have no idea.