With some exceptions. You need to go through this forum to look for like 2 mods that have the wrong installation instructions. X Caliber is one of them, I forgot the rest.
Anyways, I installed this on a friend's PC and it works perfect with one issue currently: glitches in Fiend territory worldspace where bullets and ammo are shoot in slow motion and enemies that die are floating in midair. We also couldn't complete any quests in this area, because we start going super slow.
I say his install went better than the install I did awhile back. Go for it before more updates make this guide obsolete.
PS: Don't bother looking for an all-in-one mod package for New Vegas, it doesn't exist and it's good to support each mod creator by going to each page individually so they know we're still running this game in 2017.