i just reinstalled Skyrim and followed STEP:Core v2.2.9. I added RealVisionENB and some of the recommended Mods as well as some others (mainly Witcher type stuff).
Everything was done with ModOrganizer, sorted by LOOT and bashpatched with WryeBash. The only changes in the INI files are the ones described in STEP and RealVisionENB.
The game runs smoothly and there are no CTDs, even after several houres of play, but every magic i cast (be it from a staff or from my hands) goes off to the top left of where i aim (see Screenshots).
Lesser Ward, Clearvoiance and the Witcher Aard Spell seem to work correctly, but i didn't test many others.
The only mods i could think of which could interfere are "Dualsheath Redux" and "1hWeapons on Back" but removing them did nothing to help my problem.
I'm NOT new to modding but i never encountered this specific bug and google was no help.
My Full Modlist: