I've been trying this out and it's a really impressive mod. Looks good with the enb I'm currently using (vividian vivid) with much less of the glowing skin effect I was getting before.
Regarding compatability with Better Males.. the main issue seems to be that the foot mesh in that mod can't be used with SkySight. So if installing SkySight on top of Better Males you would have to hide/remove the meshes folder of Better Males. That means going back to the vanilla foot mesh, but I'm ok with that.
Better Males also has it's own underwear texture. It seems fine with SkySight (though tbh I didn't spend much time looking). It also has some tints/scars etc which I think would be fine to leave.
I don't think there are any other issues.. Skysight overwrites everything else, with the exception of the beast races which Better Males would still provide.
Please correct me if I'm wrong and missed something, I'm not experienced with these things.