Looking at Follower mod, I was intrigued by the use of hot keys, particularly the ability to hot key a wait command. get followers to wait, move and scout (lay traps, etc), then pull enemy and retreat to followers. Or, have a mule follower, and just get them to wait a little way back.
I also used a previous version some time back, and was quite impressed with the class system, healer followers would actually heal you (super powerful for melee fighters), rangers (i.e. non melee fighters) would actually keep range and run away from charging enemies, and mages would actually mage (i.e. shoot magic, and NOT run forward and punch the saber cat and getting mauled).
Also opening multiple followers bags at once when you are looting so that you don't have to walk around redistributing stuff.