First off, I have not run Skyrim LE from MO2 so there may be a problem I am not aware of when using SKSE. You can always download the archive version of MO1.xx and copy it to a temporary directory, pointing it to the MO2 folders and test to see if it works from MO1. If it works, then MO2 install most likely is bad.
Where did you download MO2 and how did you install it? MO2 is constantly being updated on the discord server, while the Nexus version will be static until the next release. You may want to go over there and download the most recent version under the Builds channel. It is only an archive download and copy and paste to update. Should be easy depending on your level of PC experience. Just ask is you have questions. The link to the discord site is on the first comment of the posts tab of the Skyrim SE Nexus page.
When installing MO 2 do not install to a Windows UAC protected folder and it should not be installed into the games directory. It should be installed in its own directory on any drive on your system.
When you download an archive and after it finishes downloading you want to right click on it and select properties from the selection. At the bottom right, you should see a security section. There will should be a box next to “Unblock” which will need to be checked. Click apply and Ok. You can now extract and copy the archive to its destination.
Some other things you can check:
Under settings (the wrench and screwdriver icon) go to the workarounds tab and make sure that the “Load mechanism” is set to Mod organizer.
SKSE: I see by the SKSE mod that you have v1.07.03 installed and by the icon the scripts are installed. Make sure it is the version for the Skyrim LE and not Skyrim SE. I would download the 7z archive and install that way instead of using the installer version. Remember to unblock it as stated above. Copy skseXXX.dll, skse_loader.exe and skse_steam_loader.dll to the Skyrim root directory of the game.
If you can please provide a screenshot of the Paths tab from the settings