Hey,
I've been getting constant freezes near Wilhelm's Wharf. If I save spam near the crash area I can eventually get inside without freezing, but my game will stutter like crazy and eventually just crash anyways. Anywhere else in the wasteland seems to run fairly smoothly, except in that one area. I do have FOSR disabled and replaced with F3TF - Fallout 3 Tick Fix, FOSR tends to make my game run like **** for whatever reason. I'm out of ideas and its making me sad. 
Load Order:
0 0 Fallout3.esm
1 1 Anchorage.esm
2 2 ThePitt.esm
3 3 StreetLights.esm
4 4 BrokenSteel.esm
5 5 PointLookout.esm
6 6 Zeta.esm
7 7 Unofficial Fallout 3 Patch.esm
8 8 CALIBR.esm
9 9 Advanced Recon Tech.esm
10 a Point Lookout Reborn.esm
11 b Mart's Mutant Mod.esm
12 c ArefuExpandedByAzar.esm
13 d DCInteriors_ComboEdition.esm
14 e Mothership Crew.esm
15 f Enhanced Weather - Rain and Snow.esm
16 10 iHUD.esm
17 11 Inventory Access.esm
18 12 Vault 101 Revisited.esm
19 13 RiversideCafe.esm
20 14 WastelandGuards01.esm
21 15 CRAFT.esm
22 16 FO3 Wanderers Edition - Main File.esm
23 17 Project Beauty.esm
24 18 EVE.esm
25 19 Detect Traps.esm
26 1a aHUD.esm
27 1b GeorgetownExpansion.esm
28 1c RH_IRONSIGHTS.esm
29 1d xCALIBR.esm
30 1e Xepha's Dynamic Weather.esm
31 1f Crowded Cities Redux.esm
32 20 AWorldOfPainFO3.esm
33 21 Simply Uncut.esm
34 22 TheInstitute.esm
35 23 DocLeskosResearch.esm
36 24 tubrrCompound.esm
37 25 FCOMaster.esm
38 26 ImaginatorFO3.esp
39 27 PlasmaRifleAwesomefied.esp
40 28 UF3P - Exotic Caravans.esm
41 29 DarNifiedUIF3.esp
42 2a STDG.esp
43 2b MetroCars.esp
44 2c FortIndependenceRedesigned.esp
45 2d ArlingtonRestoration.esp
46 2e The Mantis Imperative - Mantis.esp
47 2f FO3 Wanderers Edition - Main File.esp
48 30 WeaponModKits.esp
49 31 WeaponModKits - FWE Master Release.esp
50 32 FO3 Wanderers Edition - DLC Broken Steel.esp
51 33 FO3 Wanderers Edition - DLC Anchorage.esp
52 34 FO3 Wanderers Edition - DLC Mothership Zeta.esp
53 35 FO3 Wanderers Edition - DLC The Pitt.esp
54 36 UUF3P - FWE Patch.esp
55 37 IMPACT.esp
56 38 Blackened FWE + MMM + EVE + Project Beauty.esp
57 39 DC Moods.esp
58 3a SafeMerge.esp
59 3b Realistic Interior Lighting.esp
60 3c Rivet City Realignment.esp
61 3d Temple of the Union Overhaul.esp
62 3e The Mantis Imperative - Jello.esp
63 3f HeirApparent.esp
64 40 Another Interior Mod.esp
65 41 Advanced Recon Tech FWE.esp
66 42 Advanced Recon Tech.esp
67 43 Advanced Recon Range Finder.esp
68 44 Stimpak Counter.esp
69 45 PPA - The Pitt.esp
70 46 JIP Realistic Weapon Overheating.esp
71 47 JIP Selective-Fire.esp
72 48 CASM.esp
73 49 rmSaveManager.esp
74 4a Overhead3PCamera.esp
75 4b YearlingBooks.esp
76 4c Confessor Cromwell has a Break_EV.esp
77 4d PointLookout Moods.esp
78 4e 01AtM - Firefly Ranch.esp
79 4f tubRRCompound.esp
80 50 A Little Mutant Problem.esp
81 51 DCInt_ARoomWithAView.esp
82 52 The Pitt Moods.esp
83 53 WeaponModKits - BrokenSteel.esp
84 54 WeaponModKits - ThePitt.esp
85 55 WeaponModKits - Zeta.esp
86 56 lexx_brahmin-variant-Fo3.esp
87 57 JIP Companions Command & Control.esp
88 58 WeaponModKits - FWE Talon Loot Crash Fix.esp
89 59 FWEAlienWorkBenchFix.esp
90 5a Enhanced Weather - Weather Sounds in Interiors.esp
91 5b Xepha's Dynamic Weather - Dynamic Sneak Bonus.esp
92 5c Xepha's Dynamic Weather - Rain.esp
93 5d Xepha's Dynamic Weather - Sandstorms.esp
94 5e Xepha's Dynamic Weather - Weather Machine (Vendor Added).esp
95 5f krzymar-MoonSize_120%.esp
96 60 UrgeWashingtonBoS.esp
97 61 Project Beauty- Broken Steel.esp
98 62 Project Beauty- Point Lookout.esp
99 63 K9Breeds.esp
100 64 FeralGhoulTest.esp
101 65 GlowingGhouls-MMM.esp
102 66 RagdollOverhaulFo3.esp
103 67 T3_leather armors.esp
104 68 Headwraps Galore.esp
105 69 Merc Adventurer Armor - eng.esp
106 6a Merc Adventurer Armor - rus.esp
107 6b Real Radiation Suit FO3.esp
108 6c Tribal_DX.esp
109 6d EVE Grenade Explosion.esp
110 6e Millenia_AKS74U.esp
111 6f schematics2.esp
112 70 GNR Enhanced.esp
113 71 WeaponModKits - OperationAnchorage.esp
WMK Uniques for FWE_EVE Addon.esp
114 72 Armor Repair Kits PL - FO3.esp
Zeta Turret Drone Karma Fix - MMM Merged.esp
PPA - FWE Tougher NPC Power Armour.esp
115 73 WeaponModKits - PointLookout.esp
116 74 RH_WMK_Bridge.esp
DIFF WMK.esp
117 75 DIFF.esp
118 76 Blackened RH + FWE + EVE.esp
119 77 FO3 Wanderers Edition - DLC Point Lookout.esp
120 78 PLweightadjust.esp
121 79 ChopShopModv13.esp
122 7a FO3 Wanderers Edition - More Gore.esp
FO3 Wanderers Edition - Optional Restore Tracers.esp
123 7b NotSoFast.esp
124 7c CALIBRv14 Ammunition Schematics for FWE-WMK-CRAFT-V1_3-18639.esp
125 7d MoreMapMarkers.esp
126 7e BaileysCrossingMetro.esp
127 7f BBBackpacks-v1-1.esp
128 80 Compiled fixes for Fallout 3 ( compatible with UOFO3P ).esp
129 81 BauPetSupplies.esp
130 82 TrentonTowers.esp
131 83 K9BreedsMoreDogs.esp
132 84 Dragonskin Tactical Outfit.esp
133 85 Advanced Recon Gear.esp
134 86 Detect Traps - The Traponator 4000.esp
135 87 Museum.esp
136 88 Tinker Joe fix for UOF3P.esp
137 89 PotomacSteamworks.esp
138 8a Dree Perks.esp
139 8b CanterburyCommonsInteriors.esp
140 8c A Trail of Crumbs.esp
141 8d Powered Power Armor.esp
142 8e PPA - FWE.esp
143 8f PPA - Broken Steel.esp
144 90 PPA - Operation Anchorage.esp
145 91 RiversideCafe.esp
146 92 Radio Ownership Fix Fixed.esp
147 93 AutoGates.esp
148 94 Better RC Church.esp
149 95 BornAgain Outcast v3.esp
150 96 DragonskinBonusPack.esp
151 97 HKG3.esp
152 98 ZL-ACR.esp
153 99 Assaultrifle_replacers_WMK+RH+FWE.esp
154 9a dD - Enhanced Blood Main.esp
155 9b Radio_Neutron.esp
156 9c Brahmin Dairy Products.esp
157 9d megalight.esp
158 9e ZL-MP5 Pack.esp
PPA - FWE 2.esp
Dragonskin_for_FWE_2014.esp
MP5ForFWE.esp
159 9f Boulevard of Broken Dreams.esp
160 a0 IntoTheDeepWoods.esp
161 a1 Existence 2.0.esp
162 a2 ArefuExpandedByAzar-Radio.esp
163 a3 NewMall.esp
164 a4 MusTechGenRoom.esp
165 a5 Scout Outfits.esp
166 a6 RockopolisRebuilt.esp
167 a7 ZL-SVD-CALIBR.esp
168 a8 GilbertToys.esp
169 a9 Conelrad 640-1240.esp
170 aa Lookout Outfits.esp
171 ab Tattered_suits.esp
172 ac MTCBigTownRobotFix.esp
173 ad Purity Crash Fix.esp
174 ae PAL - MERGED.esp
175 af Freebooter_Armor.esp
176 b0 DIM TYPE3clothesRETAIL.esp
177 b1 FO3NeckChains.esp
178 b2 PPA - Mothership Zeta.esp
SVDForFWE.esp
(TWPC) BBD-FWE Patch.esp
(TWPC) DIFF3-UUF3P-FWE Patch.esp
179 b3 UniqueWeaponsRetextured.esp
UniqueWeaponsRetextured_FWE.esp
180 b4 PlasmaRifleAwesomefiedWMK.esp
Hi-Res Weapons & Ammo Textures.esp
181 b5 WinterizedT51bDX.esp
Winterized_T51b_Patch.esp
182 b6 WMKAA12Shotgun.esp
DeNerfing Colonel Autumns Laser Pistol.esp
183 b7 Deathclaw Gauntlet Man Opener Armor Piercing Restored.esp
184 b8 UniqueWeaponsRetexturedPITT.esp
UniqueWeaponsRetexturedPITT_FWE.esp
(TWPC) MMM-EBTMGFWE-UUF3P-FWE Patch.esp
(TWPC) PLR-MMM Patch.esp
(TWPC) WMK-UUF3P-FWE Patch.esp
ACRforFWE.esp
ZL-MP5_fix.esp
CPD_General_Patch.esp
185 b9 Xepha's Dynamic Weather - Main + DLC Merged.esp
186 ba (TWPC) DM-UUF3P-DW Patch.esp
187 bb PLFewerItems.esp
188 bc Bashed Patch, 0.esp
189 bd (TWPC) RIL-UUF3P-DM Patch.esp
(TWPC) BBB-UUF3P-FWE Patch.esp
190 be (TWPC) PLR-UUF3P-ISS Patch.esp
(TWPC) BFO-MMM-EVE-UUF3P-FWE Patch.esp
(TWPC) BRCC-PB Patch.esp
(TWPC) BVR-FWE Patch.esp
(TWPC) CMRP-FWE Patch.esp
(TWPC) GE-UUF3P Patch.esp
(TWPC) K9B-MMM-UUF3P-FWE Patch.esp
(TWPC) RRE-PB-FWE Patch.esp
(TWPC) TMI-FWE Patch.esp
(TWPC) WD-DIFF3-UUF3P-FWE Patch.esp
CPD_Ingestible_Patch.esp
Specs:
Windows 10 Pro Build 18362
I7-8700k 5.0ghz
GTX 1070
16gb RAM