JudgmentJay - I assume you are basing this on personal experience? Any idea what kind of ratio of VRAM is loaded into RAM? It obviously isn't 1 to 1 (otherwise it couldn't use unlimited VRAM). I might run a test tonight to remove all of my textures from MO and see how Ram and VRAM change. I'll post results.
Yes, it's based on extensive personal experience. I'm not sure the exact ratio... I don't check VRAM usage much, but I always have physical RAM usage displayed on the screen when I'm messing around with mods. When I go from a vanilla install to a vanilla install + Texture Pack Combiner, it's +~600mb of physical RAM usage when loading into Riverwood.