Very much yes. This is also why some make specific weather .esp´s etc for their ENB.. since then they have full control over the visuals. Building on top of the vanilla ones is just a cause for headaches for a number of reasons. This is especially true for interiors, which is why ELE image spaces should always be used.
In general there is only one set of values for ALL interiors in ENB, hence you need to create the foundation and diversity of your interiors from an .esp.
Also skyrim is a huge game, and most preset creators do not actually spend much time playing the game so they do not go test in every single location of the game. This is another reason ELE is so good.. you do not have too. If you make a few choice locations look good you know ALL will look good.
For the player this is also a good thing, since this means you can quickly test in a number of locations and see if you like what you see and then know that this is how it will be everywhere.. to varying degrees ofc.
Another bonus is that it also makes it very easy for you to tweak a preset to your liking if you want it a little bit brighter for example. Since it is just one value you need to change, and in some presets you can do all of this from ingame... so no need to go out and look around in the code etc.
In general I would only recommend ENB presets which have GUI control of their shader files as well.. if they do not it is not as easy to tweak them, and generally mean that they are really really outdated. Ofc. they can still look really good, but it is always nice to have the ability to tweak those few things you might not like.
As for presets to check out.. and which cover a rather wide range of different visuals styles are
Vividian By Mangaclub and benhat
Serenity By Prod80
Natural lighting and Atmospheric by Confidenceman
Insomnia by Insomnia
Sombre 3 by Maeldun0
Grim and Sombre collection by Wolfgrimdark
Finally you can check out Skylight by me.
If you can find a version of K ENB those are also most definitely worth checking out. Those files are not on the nexus anymore due to various reasons.
Ofc. if you find you do not want the latest effects like cloud shadows etc. etc. then you can never go wrong with project ENB, or seasons of skyrim, and in general all who are made by bronze316. Skyrealism by indegonecko is also worth checking out.
I could ofc continue to phrase up the entire list of presets.... but those will at least get you started. There are many more very good ones out there as well.