A thing I've noticed, the two Fallout version Wrye Flashs don't generate a blank bashed patch when you first run them.
Or if, as some do, you de-activate your existing patch and want to make a new one, you can't. Is this intentional or is just my installs that are wonky?
If you want different profiles with different patches you need to do a bit of backroom copy/paste to make folders and copy a blank bashed patch first and then run Wrye.