OK, I didn't see that part as you edited your post after I posted my response.
Did you install this version of FNV4GB? : https://www.nexusmod...gas/mods/55061/
Did you properly install NVSE? Did you heed the instructions of FNV4GB? (quoted from FNV4GB's Nexus webpage) : "First, make sure you have launched the game with the default launcher AT LEAST ONCE after setting up your graphics options or the program will NOT function properly."
Yes (I've even tried the older version, just in case), and yes.
This highlighted section is the key I believe. If you can get the FNV4GB patcher to run with a basic install and only a few mods then the issue isn't with either MO or FNV4GB, it is with one of those mods.
I would suggest examining your NVSE installation and/or the mods that require it. It could also be a case of the patcher working fine but your systm simply falls under the pressure of too much texture load.
If you could post the contents of you 'heavy' profile and you ModOrganizer.ini along with you system specs that might assist us.
I kind of figured it was something mod related, although I wasn't aware that texture load could be a factor.
I could run a roughly similar mod load out with, IIRC, the exact same graphical mods, back when I was using fallout mod manager, so while my computer isn't very powerful, I'm not sure why it would suddenly be unable to run it
Edited by tighearnachcreag, 03 July 2015 - 08:52 PM.