Well just to add my two pence to the opinions ( without having any kind of in depth knowledge of the subject, but a rough edged idea of some of what the Crash Fixes ini details ) ..
I do not have a heavily modded game ( habit ever since modding Oblivion, keeping things in moderation has always kept my game setups highly stable ), so really am not the ideal candidate to be doing any kind of testing but thought I would give it a run
I never have CTDs so mostly I expect any feedback I have will be not much use at all
Previously using Shesons memory fix via SKSE ini, but I dont think I ever really needed it.
Now using Plugin Preloader, and Crash fixes with the equivalent of shesons fix enabled, and SKSE ini has had the Sheson fix settings removed
The rest of the settings in the Crash Fixes ini I have left at default
The only remarkable difference I have noticed is that with SKSE Sheson fix, game loading was generally 2-3 seconds longer than vanilla game setup
With the new Plugin Preload and Crash Fixes setup, that delay has now gone completely.
So in my case at least it has been beneficial if only for that.
On my new I7 machine I have a rare slight stutter at cell loads, but that mostly goes un-noticed. Now that I am looking for it since changing over to Crash fixes, I have not seen any recurrence. Going to keep it installed for a good length of time ( been trying SKSE Memory patch for about a year un-necessarily in my case, so why not :) )
I also kicked off another topic on AFK Mods forum in case there is anyone else venturing into testing it out can offer more feedback who does not frequent this forum.