I'm running this with Safety Load, SKSE loader (default 768 memory block) & ENB. I just had Skyrim run out of memory in Riverwood (alternate start: camping in the woods) after sneaking into town. My ExpandSystemMemoryX64 was set to "true". I've adjusted that to "false" and was able to start a new, sneak into town, hunt the local forests & get up to mischief in the Sleeping Giant without incident. As you say, time will tell.
I thought Safety Load had been put on the "Burn this Mod before it burns your game" list?